Key result
The hypertriglyceridemic-waist phenotype was associated with an increased risk of incident cardiovascular disease compared to a normal phenotype.
Why the study?
The association between hypertriglyceridemic-waist phenotype and cardiovascular disease remains inconsistent and debatable.
Does the hypertriglyceridemic-waist (HTGW) phenotype increase the risk of incident cardiovascular disease in adults aged 45 years and older?
Cohort (n=8,216)
Yes
Does the hypertriglyceridemic-waist (HTGW) phenotype increase the risk of incident cardiovascular disease in adults aged 45 years and older?
The hypertriglyceridemic-waist phenotype is an independent predictor of incident cardiovascular disease, suggesting its utility as a simple, inexpensive clinical screening tool for identifying high-risk patients.
Answers are grounded in this paper and cite their sources.
HTGW phenotype associated with higher CVD risk; supports screening utility but leaves open need for prospective validation.
Background The association between hypertriglyceridemic-waist (HTGW) phenotype and cardiovascular disease (CVD) remains inconsistent and debatable. We aimed to prospectively investigate the relationship between HTGW phenotype and CVD. Methods and results We included 8,216 participants from the China Health and Retirement Longitudinal Study. Participants were categorized into four subgroups: NTNW: normal triglyceride levels and normal waist circumference; HTNW: high triglyceride levels and normal waist circumference; NTGW: normal triglyceride levels with enlarged waist circumference; HTGW: high triglyceride levels and enlarged waist circumference. A Cox proportional hazards model was applied to determine the association between HTGW phenotype and CVD. A meta-analysis was conducted to incorporate the results of the current study and the previous-related studies on the association of HTGW phenotype and CVD. In the present cohort study, compared to the NTNW phenotype, those with NTGW (Hazard ratios ( HRs ) 1.34, 95% confidence intervals ( CIs ) 1.16–1.55) and HTGW ( HRs 1.37, 95% CIs 1.16–1.62) phenotype were significantly associated with CVD risk. The meta-analysis further confirmed the significant association between HTGW phenotype and CVD [the pooled relative risk for HTGW vs. NTNW was 1.39 (1.29–1.49)]. Conclusion The HTGW phenotype was associated with the increased risk of CVD, independently of established risk factors. A simple assessment of HTGW phenotypes might help to identify individuals with a high risk of developing CVD.
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Zheng et al. (2022) conducted a cohort in Cardiovascular disease (n=8,216). Hypertriglyceridemic-waist (HTGW) phenotype vs. Normal triglyceride levels and normal waist circumference (NTNW) was evaluated on Incident cardiovascular disease (stroke or cardiac events) (HR 1.37, 95% CI 1.16-1.62, p=<0.001). The hypertriglyceridemic-waist phenotype was associated with an increased risk of incident cardiovascular disease compared to a normal phenotype.
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