Key result
The hypertriglyceridemic waist phenotype was significantly associated with higher odds of hypertension compared to a normal waist and triglyceride phenotype (adjusted OR 1.28; 95% CI 1.04-1.58).
Why the study?
The study was designed to evaluate the relationship between the hypertriglyceridemic waist phenotype and hypertension.
Is the hypertriglyceridemic waist phenotype associated with an increased prevalence of hypertension in middle-aged and older Chinese adults?
Cross-Sectional (n=9,015)
Is the hypertriglyceridemic waist phenotype associated with an increased prevalence of hypertension in middle-aged and older Chinese adults?
Odds Ratio: 1.28 (95% CI 1.04–1.58)
Absolute Event Rate: 89.9% vs 75.3%
p-value: p=< .001
The hypertriglyceridemic waist phenotype is independently associated with a higher prevalence of hypertension in Chinese adults, suggesting its utility as a simple clinical risk marker.
HTGW phenotype may mark higher hypertension risk in Chinese adults; leaves open causal role and predictive utility in prospective studies.
The present study aimed to evaluate the relationship between the hypertriglyceridemic waist (HTGW) phenotype and hypertension. We undertook a cross-sectional study with a sample of 9015 adults from China. The HTGW phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Logistic regression analysis was used to evaluate the association between the HTGW phenotype and hypertension. The prevalence of hypertension was significantly higher in individuals with the HTGW phenotype, than in those with the normal waist normal triglyceride (NWNT) phenotype (89.9% vs 75.3%, respectively, P < .001). After adjusting for age, sex, BMI, current smoker, and current alcohol consumption, the HTGW phenotype was associated with hypertension (Odds Ratio (OR)1.53; 95% CI 1.25-1.87). After further adjustment for potential confounders, the HTGW phenotype was still significantly associated with hypertension (adjusted OR1.28; 95% CI 1.04-1.58) regardless of sex. The subgroup analyses generally revealed similar associations across all subgroups. This study indicated that the HTGW phenotype was strongly associated with hypertension, and blood pressure should be clinically monitored in individuals with the HTGW phenotype. We suggested a combined use of hypertriglyceridemia waist phenotype in identifying participants who are at high risk of hypertension.
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Xuan et al. (2022) conducted a cross-sectional in Hypertension (n=9,015). Hypertriglyceridemic waist (HTGW) phenotype vs. Normal waist normal triglyceride (NWNT) phenotype was evaluated on Hypertension (OR 1.28, 95% CI 1.04-1.58, p=< .001). The hypertriglyceridemic waist phenotype was significantly associated with higher odds of hypertension compared to a normal waist and triglyceride phenotype (adjusted OR 1.28; 95% CI 1.04-1.58).
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