Key result
Hypertriglyceridemic waist phenotype is linked to a ~130% higher risk of decreased eGFR.
Why the study?
Evidence on the relationship of triglyceride waist phenotypes with estimated glomerular filtration rate status and severity was limited.
Cross-Sectional (n=31,296)
Yes
Answers are grounded in this paper and cite their sources.
Hypertriglyceridemic waist phenotype associated with reduced eGFR; hypothesis-generating and requires prospective validation before clinical consideration.
Background: The hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD), but evidence on relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity is limited. Our aim was to explore the association of triglyceride waist phenotypes with reduced eGFR and various decreased eGFR stages among Chinese adults.Methods: A population-based, cross-sectional study was conducted among Chinese participants aged 20-74 years during June 2016 to December 2017 in Shanghai, China. An eGFR value below 60 mL/min/1.73 m2 was defined as Decreased eGFR. The HTGW phenotype was defined as a triglycerides (TG) level ≥1.7 mmol/L and a waist circumference (WC) ≥90 cm for men and ≥80 cm for women. We examined the association of triglyceride waist phenotypes with decreased eGFR risk using the weighted logistic regression models.Results: A total of 31,296 adults were included in this study. Compared with normal TG level/normal WC (NTNW) phenotype, normal TG level/enlarged WC (NTGW), elevated TG level/normal WC (HTNW), elevated TG level/enlarged WC (HTGW) were associated with the increased risk of decreased eGFR, with an multivariable-adjusted ORs (95% CI) of 1.77 (1.42-2.20), 1.48 (1.16-1.90), and 2.30 (1.80-2.93), respectively. These positive associations between triglyceride waist phenotypes and decreased eGFR risk remained across almost all the subgroups, including sex, age, BMI, T2DM, and hypertension. NTGW, HTNW, and HTGW phenotype were consistently positively associated with the risk of mildly and moderately decreased eGFR, but not with severely decreased eGFR risk.Conclusions: HTGW was consistently associated with the increased risk of decreased eGFR and various decreased eGFR stages except for severely decreased eGFR. The findings imply that HTGW may be an important risk factor for renal dysfunction or an indicator for prevention and control aiming to reduce renal function decline.
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Zhao et al. (2020) conducted a cross-sectional in Decreased estimated glomerular filtration rate (eGFR) (n=31,296). Hypertriglyceridemic waist (HTGW) phenotype vs. Normal triglyceride level and normal waist circumference (NTNW) phenotype was evaluated on Decreased eGFR (<60 mL/min/1.73 m2) (OR 2.30, 95% CI 1.80-2.93, p=<0.001). The hypertriglyceridemic waist phenotype was associated with a significantly increased risk of decreased estimated glomerular filtration rate compared to the normal phenotype (OR 2.30).
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