Why the study?
The study sought to investigate the relationship between the hypertriglyceridemic-waist phenotype, a screening tool for cardiovascular and glycemic metabolic disease, and non-alcoholic fatty liver disease.
Is the hypertriglyceridemic-waist phenotype associated with an increased risk of non-alcoholic fatty liver disease in the general population?
Population
14,251 subjects who took part in health screening
Comparison
Four phenotypes based on triglyceride and waist circumference levels
Design
Cross-sectional study
Key result
The hypertriglyceridemic-waist phenotype was associated with a 160% increased risk of non-alcoholic fatty liver disease (OR 2.60) compared to individuals with normal waist circumference and triglycerides.
Authors
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May support NAFLD screening in primary care; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=14,251)
No
Is the hypertriglyceridemic-waist phenotype associated with an increased risk of non-alcoholic fatty liver disease in the general population?
Odds Ratio: 2.6 (95% CI 1.88–3.58)
Absolute Event Rate: 77.81% vs 10.29%
The hypertriglyceridemic-waist phenotype is strongly associated with non-alcoholic fatty liver disease and may serve as a practical screening indicator.
Yang et al. (2022) conducted a cross-sectional in Non-alcoholic fatty liver disease (n=14,251). Hypertriglyceridemic-waist (HTGW) phenotype vs. Normal waist circumference and normal triglyceride levels (NTNW) was evaluated on Non-alcoholic fatty liver disease (NAFLD) (OR 2.60, 95% CI 1.88-3.58). The hypertriglyceridemic-waist phenotype was associated with a 160% increased risk of non-alcoholic fatty liver disease (OR 2.60) compared to individuals with normal waist circumference and triglycerides.