Key result
Degenerative joint diseases were associated with significantly decreased hexose and protein contents of plasmamucoid compared to rheumatoid arthritis and ankylosing spondylitis.
Observational (n=256)
Plasmamucoid and erythromucoid constituents differ significantly between degenerative joint diseases, inflammatory arthropathies, and cardiac lesions, suggesting metabolic differences.
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Plasmamucoid levels should not yet inform arthropathy diagnosis; hypothesis-generating for metabolic distinctions and requires prospective validation.
SummaryIn two groups of degenerative joint diseases (88 + 23) as compared to rheumatoid arthritis (40 + 33) and ankylosing spondylitis without subclinical diabetes (41) the hexose and protein contents of plasmamucoid are significantly decreased. The plasmamucoid protein content found in degenerative joint diseases shows a significant rise as compared with the group of inflammatory and degenerative cardiac lesions without clinical arthropathy (31) and with predominance of ischemic heart disease.The diseases were classified metabolically according to the plasma and erythromucoid constituents. The classification is in agreement with clinical manifestations of these diseases. From the present study follows that in the pathogenesis of degenerative joint diseases the metabolism of carbohydrates and hypoxia should be studied in further investigations.
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Štěpán et al. (1969) conducted an observational in Degenerative joint diseases (n=256). Degenerative joint diseases vs. Rheumatoid arthritis, ankylosing spondylitis, and cardiac lesions was evaluated on Hexose and protein contents of plasmamucoid. Degenerative joint diseases were associated with significantly decreased hexose and protein contents of plasmamucoid compared to rheumatoid arthritis and ankylosing spondylitis.
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