Key result
Fenestrated ASD closure successfully controlled pulmonary blood flow, achieving a Qp/Qs of 1.3, in a 5-month-old infant with hypertrophic cardiomyopathy and an atrial septal defect.
Why the study?
ASD rarely becomes severe in early infancy, and HCM with left ventricular diastolic dysfunction carries a poor prognosis when complicated by congenital heart disease.
Does fenestrated ASD closure improve hemodynamics in an early infant with ASD, HCM, and left ventricular diastolic dysfunction?
Case Report (n=1)
No
Does fenestrated ASD closure improve hemodynamics in an early infant with ASD, HCM, and left ventricular diastolic dysfunction?
Fenestrated ASD closure is a safe and effective treatment option for left ventricular diastolic dysfunction in early infants with ASD and HCM.
May support fenestrated ASD closure in select infants with ASD, HCM, and LV diastolic dysfunction; hypothesis-generating and requires prospective validation.
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Hayashi et al. (2021) conducted a case report in Hypertrophic cardiomyopathy with atrial septal defect and left ventricular diastolic dysfunction (n=1). Fenestrated ASD closure was evaluated on Pulmonary blood flow control (Qp/Qs). Fenestrated ASD closure successfully controlled pulmonary blood flow, achieving a Qp/Qs of 1.3, in a 5-month-old infant with hypertrophic cardiomyopathy and an atrial septal defect.
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