April 1, 1994Cardiology in the Young

Frequency and severity of endocardial fibroelastosis in dilated hearts from children—endocardial thickness is inversely correlated to age

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Population

21 necropsy hearts from children with dilated cardiomyopathy, ages 2 to 175 months

Design

Cross-sectional

Authors

VAVera Demarchi AielloUniversidade de São Paulo MHMaria de Lourdes HiguchiUniversidade de São Paulo

Discussion

Member takes

Implication

Does not support altering pediatric cardiomyopathy management; leaves open whether endocardial thickening is a modifiable, age-dependent secondary process.

Structured PICO

Population

21 necropsy hearts from children with dilated cardiomyopathy, ages 2 to 175 months (mean 46.5, median 23 months)

Comparator

Hearts from 4 children presenting with tetralogy of Fallot

Outcome

Endocardial thickness measured grossly and microscopicallysurrogate

Endocardial fibroelastosis in dilated hearts of children is inversely correlated with age, suggesting it is a secondary phenomenon related to greater replicative and secretory potentials of endocardial cells in younger patients.

Cite This Study

Aiello et al. (1994) studied this question.

synapsesocial.com/papers/6a9760a2923bb7518ba666fa https://doi.org/10.1017/s1047951100002031

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Implication

Does not support altering pediatric cardiomyopathy management; leaves open whether endocardial thickening is a modifiable, age-dependent secondary process.

Frequency and severity of endocardial fibroelastosis in dilated hearts from children—endocardial thickness is inversely correlated to age

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Frequency and severity of endocardial fibroelastosis in dilated hearts from children—endocardial thickness is inversely correlated to age

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider