Histological Study of Malignant Lymphomas Treated with Intralymphatic Injection of Lipiodol F I 181

The results of histological examination of lymph nodes in 18 cases of lymphosarcoma, reticulum-cell sarcoma, and Hodgkin's disease, treated with Lipiodol F I 181 through the lymphatic vessels, are reported. The most significant changes induced by this therapy consisted of optically empty cavities of different shape and size; of degenerative changes of the neoplastic cells; of stromal reactions, with hystiocites and giant cells. These changes were of various degrees, according to the type of tumor and the amount of Lipiodol F I 181 injected. The authors believe that the histological data presented, together with the clinical and radiological results already published, confirm the effectiveness of the intralymphatic radiotherapy in the treatment of malignant lymphomas.