Key result
Visceral obesity in men with myocardial infarction was associated with increased proinflammatory cytokines (up to 24-fold for IL-8 and CRP) and decreased IL-10.
Why the study?
The relation between key inflammatory factors and myocardial infarction complications across disease stages in patients with visceral obesity had not been fully assessed.
Does visceral obesity alter the inflammatory cytokine profile and long-term prognosis in men with myocardial infarction?
Observational (n=124)
Does visceral obesity alter the inflammatory cytokine profile and long-term prognosis in men with myocardial infarction?
Visceral obesity in men with myocardial infarction is associated with a highly pro-inflammatory cytokine profile and adverse cardiovascular complications at one year.
May flag higher post-MI inflammatory risk; leaves open whether targeting visceral obesity improves outcomes.
Objective: To assess the relation between key factors of inflammation and myocardial infarction complications in different stages of the diseases in patients with visceral obesity. Methods: Men with the diagnosed myocardial infarction were examined: 64 of them with visceral obesity (the first group) and 30 of them without visceral obesity (the second group). On the 1s t and 12th day of hospitalization, the serum concentrations of interleukins (IL) 1β, 6, 8, 10 and 12, tumor necrosis factor α (TNFα) and C-reactive protein (CRP) were determined. The control group included 30 healthy men. Results: The cytokine profile in visceral obesity was characterized by the increase in concentration of proinflammatory ILs and the decrease in concentration of IL-10. The concentration increase was: 1.3 times for IL-1 and TNFα, 2 times for IL-12, 6 times for IL-6 and 24 times for IL-8 and CRP. The increase in IL-6 and CPR levels in blood serum was associated with the obesity. Conclusions: The development of adverse cardio‑ vascular complications a year later after the previous myocardial infarction is typical for patients with visceral obesity and is followed by the activation of proinflammatory cytokines and deficiency of IL-10.
No takes yet. Share an insight, caveat, or question.
Учасова et al. (2020) conducted an observational in Myocardial infarction and visceral obesity (n=124). Visceral obesity vs. No visceral obesity and healthy controls was evaluated on Serum concentrations of proinflammatory cytokines and cardiovascular complications. Visceral obesity in men with myocardial infarction was associated with increased proinflammatory cytokines (up to 24-fold for IL-8 and CRP) and decreased IL-10.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: