Key result
Elevated IL-6, TNF-α, and IL-6/IL-10 ratio correlate with greater coronary atherosclerosis severity in MI patients.
Why the study?
The association of cytokine status with coronary atherosclerosis severity in patients with MI was evaluated to clarify coronary atherosclerosis pathogenesis and risk prediction.
Population
92 patients hospitalized with MI and 23 control patients with stable CAD
Comparison
Patients with MI vs control patients with stable CAD
Authors
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May aid MI risk stratification; hypothesis-generating for cytokine-targeted therapies, needing prospective confirmation.
Case-Control (n=115)
No
Elevated levels of IL-6, TNF-α, and the IL-6/IL-10 ratio are associated with increased coronary atherosclerosis severity in patients with myocardial infarction.
Хлынова et al. (2020) conducted a case-control in Myocardial infarction (n=115). Cytokine levels (IL-6, TNF-α, IL-10, CRP) vs. Stable coronary artery disease was evaluated on Coronary atherosclerosis severity (Gensini score). Elevated concentrations of IL-6, TNF-α, and the IL-6/IL-10 ratio were directly correlated with coronary atherosclerosis severity (Gensini score) in patients with myocardial infarction.
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