Key result
Elevated baseline levels of IL-6 (27.45 vs 16.04 pg/mL; p<0.001) and TNF-α (24.74 vs 19.58 pg/mL; p<0.01) were associated with cardiogenic shock compared to uncomplicated myocardial infarction.
Why the study?
Are elevated serum levels of proinflammatory cytokines associated with the development of complications in patients with acute myocardial infarction?
Population
82 patients with acute myocardial infarction including uncomplicated non-Q wave MI, Q-wave MI complicated by…
Comparison
Measurement of serum levels of proinflammatory… vs Healthy controls and patients with uncomplicated…
Design
Cohort
Follow-up
14 days
Authors
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Elevated IL-6/TNF-α support risk stratification in acute MI; leaves open whether cytokine modulation prevents cardiogenic shock.
Observational (n=94)
Are elevated serum levels of proinflammatory cytokines associated with the development of complications in patients with acute myocardial infarction?
Absolute Event Rate: 27.45% vs 16.04%
p-value: p=<0.001
Elevated levels of IL-6 and TNF-α on the first day of acute myocardial infarction are associated with the development of acute left ventricular insufficiency and cardiogenic shock.
Soldatova et al. (2017) conducted an observational in Acute myocardial infarction (n=94). Proinflammatory cytokines (IL-1β, IL-6, TNF-α) vs. Uncomplicated MI / Healthy controls was evaluated on Development of acute myocardial infarction complications (cardiogenic shock) (p=<0.001). Elevated baseline levels of IL-6 (27.45 vs 16.04 pg/mL; p<0.001) and TNF-α (24.74 vs 19.58 pg/mL; p<0.01) were associated with cardiogenic shock compared to uncomplicated myocardial infarction.
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