Key result
Cardiogenic shock complicating AMI linked to a biphasic TNF alpha response peaking at ~204 pg/mL.
Why the study?
The inflammatory response and plasma interleukin level changes in acute myocardial infarction complicated by cardiogenic shock are not well characterized.
Population
1 60-year-old man with AMI complicated by cardiogenic shock
Design
Case report
Follow-up
Serial measurements at 3-hour intervals during observation period
Authors
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Single-case TNF alpha dynamics in AMI-CS are hypothesis-generating; larger studies needed before any clinical role.
Case Report (n=1)
No
Absolute Event Rate: 204.1% vs 4.35%
This case report demonstrates that acute myocardial infarction and subsequent cardiogenic shock elicit distinct, sequential peaks in systemic inflammatory markers like TNF-alpha and IL-6.
Pudil et al. (2001) conducted a case report in Acute myocardial infarction complicated by cardiogenic shock (n=1). Acute myocardial infarction and cardiogenic shock vs. Normal reference values was evaluated on Plasma TNF alpha level (pg/ml). In a patient with acute myocardial infarction complicated by cardiogenic shock, plasma TNF alpha levels reached two significant peaks, peaking at 80.11 pg/ml after infarction and 204.1 pg/ml during shock.
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