What is the clinical evidence from this study?

Study design: RCT. Population: acute myocardial infarction complicated by cardiogenic shock (n=40). Intervention: IABP therapy vs. standard care. Primary outcome: change of the quantified degree of multiorgan failure as determined by APACHE II score over a 4-day period.

What question did this study set out to answer?

Determine the prognostic value of pro- and anti-inflammatory cytokines (IL-1β, IL-6, IL-7, IL-8, and IL-10) for predicting mortality in patients with acute myocardial infarction complicated by cardiogenic shock.

August 31, 2026Clinical Research in CardiologyOpen Access

Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock

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Key result

Elevated interleukins predict mortality in infarct-related cardiogenic shock.

n=40

Authors

RPRoland ProndzinskyHeart Failure & Transplant SUSusanne UnverzagtLuther University HLHenning LemmSt. Marien Hospital

Discussion

Member takes

Implication

Randomized trial substudy reveals interleukin levels predict mortality in acute myocardial infarction complicated by cardiogenic shock, indicating inflammatory pathways influence patient outcomes.

Key Points

Determine the prognostic value of pro- and anti-inflammatory cytokines (IL-1β, IL-6, IL-7, IL-8, and IL-10) for predicting mortality in patients with acute myocardial infarction complicated by cardiogenic shock.
Conducted an inflammatory marker substudy of the prospective, randomized, controlled, open-label IABP-SHOCK trial (NCT00469248) in a single-center 12-bed university hospital intensive care unit.
Enrolled 40 consecutive patients with infarction-related cardiogenic shock randomized to standard care alone or standard care with intra-aortic balloon pump (IABP) support over a 96-hour observation period.
Quantified circulating cytokine levels and evaluated their predictive value for mortality using receiver operating characteristic (ROC) curves and multivariate analyses.
Peak values of IL-8 (AUC 0.80 ± 0.08), IL-6 (AUC 0.79 ± 0.08), and IL-10 (AUC 0.76 ± 0.08), alongside minimum values of IL-7 (AUC 0.69 ± 0.08), significantly predicted mortality in cardiogenic shock patients, whereas IL-1β showed no discriminatory capacity.
Circulating levels of the evaluated inflammatory markers were not modified or attenuated by the presence of IABP support.

Study Design

Type

RCT (n=40)

Blinding

open label

Randomization

randomized

Multicenter

PICO

Population

40 consecutive patients with acute myocardial infarction complicated by cardiogenic shock, observed over a 96-hour period.

Intervention / Comparator

IABP therapy vs standard care

Primary Outcome

change of the quantified degree of multiorgan failure as determined by APACHE II score over a 4-day period

Cite This Study

Prondzinsky et al. (2012) conducted an RCT in acute myocardial infarction complicated by cardiogenic shock (n=40). IABP therapy vs. standard care was evaluated on change of the quantified degree of multiorgan failure as determined by APACHE II score over a 4-day period. Interleukin-6, -7, -8, and -10 levels predicted mortality in patients with infarct-related cardiogenic shock (AUC for IL-8.

synapsesocial.com/papers/6a952d97a36a2b91f4f443ae https://doi.org/10.1007/s00392-011-0403-3

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Implication

Randomized trial substudy reveals interleukin levels predict mortality in acute myocardial infarction complicated by cardiogenic shock, indicating inflammatory pathways influence patient outcomes.

Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

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Also Consider