January 1, 1994Journal of Cardiovascular Pharmacology

Cytokines in Acute Myocardial Infarction

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Why the study?

Are plasma cytokine levels elevated in patients with acute myocardial infarction complicated by heart failure?

Population

Patients with acute myocardial infarction treated with early thrombolysis, including 7 with severe AMI, 11…

Design

Cohort

Authors

RLRoberto LatiniHeart Failure & Transplant MBMarina BianchiUniversity of Bergamo ECE CorrealeTufts Medical Center

Discussion

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Implication

May mark cytokine involvement in AMI with heart failure; leaves open a causal role and need for prospective trials.

Structured PICO

Are plasma cytokine levels elevated in patients with acute myocardial infarction complicated by heart failure?

Population

Patients with acute myocardial infarction (AMI) treated with early thrombolysis, including 7 with severe AMI (Killip class 3 or 4), 11 with uncomplicated AMI (Killip class 1), and control patients without AMI.

Outcome

Plasma levels of tumor necrosis factor (TNF-alpha), interleukin-1 (IL-1 beta), IL-8, soluble TNF receptor type I, and IL-1 receptor antagonist (IL-1Ra)surrogate

Circulating TNF-alpha and related cytokine receptors are elevated specifically in acute myocardial infarction complicated by heart failure, suggesting a pathogenetic role.

Cite This Study

Latini et al. (1994) studied this question.

synapsesocial.com/papers/6a7df0d06bb6a3a5bcac82a0 https://doi.org/10.1097/00005344-199401000-00001

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Cytokines in Acute Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cytokines in Acute Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider