January 1, 1994Journal of Cardiovascular Pharmacology

Cytokines in Acute Myocardial Infarction

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Why the study?

Are plasma levels of TNF and other cytokines elevated in patients with acute myocardial infarction complicated by heart failure?

Population

Patients with acute myocardial infarction treated with early thrombolysis, including 7 with severe AMI and…

Design

Cohort

Authors

RLRoberto LatiniHeart Failure & Transplant MBMarina BianchiUniversity of Bergamo ECE CorrealeTufts Medical Center

Discussion

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Implication

TNF-α elevation was associated with severe AMI complicated by HF; hypothesis-generating for cytokine-targeted therapies pending prospective trials.

Structured PICO

Are plasma levels of TNF and other cytokines elevated in patients with acute myocardial infarction complicated by heart failure?

Population

Patients with acute myocardial infarction (AMI) treated with early thrombolysis, including 7 with severe AMI (Killip class 3 or 4) and 11 with uncomplicated AMI (Killip class 1), plus control patients without AMI.

Comparator

Uncomplicated AMI (Killip class 1) and control patients without AMI

Outcome

Plasma levels of tumor necrosis factor (TNF-α), interleukin-1 (IL-1β), IL-8, soluble TNF receptor type I, and IL-1 receptor antagonist (IL-1Ra)surrogate

Circulating TNF and related cytokines are elevated specifically in acute myocardial infarction complicated by heart failure, suggesting a potential diagnostic and therapeutic role.

Cite This Study

Latini et al. (1994) studied this question.

synapsesocial.com/papers/6a7df0d06bb6a3a5bcac82a1 https://doi.org/10.1097/00005344-199401000-00026

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Implication

TNF-α elevation was associated with severe AMI complicated by HF; hypothesis-generating for cytokine-targeted therapies pending prospective trials.

Cytokines in Acute Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cytokines in Acute Myocardial Infarction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider