What question did this study set out to answer?

Evaluate serum levels and temporal profiles of hepatocyte growth factor (HGF), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) in acute myocardial infarction.

April 30, 2019Nepalese Heart JournalOpen Access

Measurement of Hepatocyte Growth Factor, Interleukin 6 and Tumor necrosis factor α in Acute Myocardial Infarction

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Why the study?

Early detection plays a key role in reducing early AMI mortality, and this study aimed to evaluate levels of prognostic cytokines HGF, IL-6, and TNF-alpha in AMI.

Are serum levels of HGF, IL-6, and TNF-α elevated in patients with acute myocardial infarction compared to healthy subjects?

Population

39 patients with AMI and 30 matched healthy subjects

Comparison

Patients with AMI vs healthy subjects

Design

Case control study

Follow-up

7 days

Authors

AKAsadallah KeshmiriBirjand University of Medical Sciences ADAli Reza DerakhshanMashhad University of Medical Sciences AFAfsoon FazlinejadMashhad University of Medical Sciences

Discussion

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Implication

Baseline IL-6 elevation and rising cytokines may aid AMI detection; leaves open validation as prognostic markers in prospective studies.

Key Points

Evaluate serum levels and temporal profiles of hepatocyte growth factor (HGF), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) in acute myocardial infarction.
Conducted a matched case-control study comparing 39 patients with acute myocardial infarction against 30 healthy controls matched for age, sex, and confounding variables.
Measured serum concentrations of TNF-α, IL-6, and HGF at baseline, day 3, and day 7 using enzyme-linked immunosorbent assay (ELISA).
Baseline serum IL-6 concentrations were significantly higher in the acute myocardial infarction group compared to healthy controls (P<0.05).
Serum levels of IL-6, TNF-α, and HGF progressively increased over 7 days in patients following ST-segment elevation myocardial infarction.

Structured PICO

Are serum levels of HGF, IL-6, and TNF-α elevated in patients with acute myocardial infarction compared to healthy subjects?

Population

39 patients with acute myocardial infarction (AMI) and 30 healthy subjects, matched for age, sex, and other possible confounding factors.

Intervention

Acute myocardial infarction (AMI)

Comparator

Healthy subjects

Outcome

Levels of TNF-α, IL-6, and HGF at baseline, 3 days, and 7 dayssurrogate

Baseline IL-6 and serial changes in IL-6, TNF-α, and HGF may serve as potential diagnostic biomarkers in acute myocardial infarction.

Cite This Study

Keshmiri et al. (2019) studied this question.

synapsesocial.com/papers/6a73a355c0a696a45e1af4fe https://doi.org/10.3126/njh.v16i1.23896

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Measurement of Hepatocyte Growth Factor, Interleukin 6 and Tumor necrosis factor α in Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Measurement of Hepatocyte Growth Factor, Interleukin 6 and Tumor necrosis factor α in Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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