Key result
Increasing levels of IL-1Ra (37%) and IL-6 (57%) at 48 hours in unstable angina were associated with a complicated in-hospital course (P<0.01).
Why the study?
Are increasing levels of IL-1Ra and IL-6 during the first 2 days of hospitalization associated with an increased risk of in-hospital coronary events in patients with unstable angina?
Population
43 patients aged 62+/-8 years admitted to the coronary care unit for Braunwald class IIIB unstable angina…
Design
Cohort
Follow-up
in-hospital
Authors
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May aid early risk stratification in unstable angina; hypothesis-generating for cytokine modulation trials.
Observational (n=43)
No
Are increasing levels of IL-1Ra and IL-6 during the first 2 days of hospitalization associated with an increased risk of in-hospital coronary events in patients with unstable angina?
p-value: p=<0.01
Increasing levels of IL-1Ra and IL-6 during the first 48 hours of hospitalization for unstable angina are associated with a complicated in-hospital course.
Biasucci et al. (1999) conducted an observational in Unstable angina (Braunwald class IIIB) (n=43). IL-1Ra and IL-6 level monitoring was evaluated on Complicated in-hospital course (p=<0.01). Increasing levels of IL-1Ra (37%) and IL-6 (57%) at 48 hours in unstable angina were associated with a complicated in-hospital course (P<0.01).
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