Key result
Stable angina pectoris is linked to ~53% higher IL-6 levels versus matched controls.
Why the study?
Increased inflammatory activity in stable angina pectoris and the relation of IL-6 levels to clinical findings in acute myocardial infarction were not well characterized.
Are inflammatory markers (IL-6 and IL-1ra) elevated in stable angina pectoris, and do IL-6 levels correlate with clinical findings in acute myocardial infarction?
Comparison
Stable angina pectoris patients vs sex- and age-matched controls
Design
Observational case-control study
Authors
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Elevated IL-6 and IL-1ra in stable angina support inflammation in chronic CAD; case-control data leave open therapeutic targeting.
Observational
Are inflammatory markers (IL-6 and IL-1ra) elevated in stable angina pectoris, and do IL-6 levels correlate with clinical findings in acute myocardial infarction?
Absolute Event Rate: 4.6% vs 3%
p-value: p=< 0.03
Increased inflammatory activity is present in both acute myocardial infarction and stable angina pectoris, supporting the role of inflammation in chronic ischemic heart disease.
Gabriel et al. (2000) conducted an observational in Stable angina pectoris and acute myocardial infarction. Stable angina pectoris vs. Sex- and age-matched controls was evaluated on IL-6 levels (ng/L) (p=< 0.03). Patients with stable angina pectoris had significantly higher levels of IL-6 (4.6 vs 3.0 ng/L, P<0.03) and IL-1ra (774 vs 490 ng/L, P<0.01) compared to matched controls.
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