Key result
Patients with acute myocardial infarction and stable angina had significantly higher serum concentrations of IL-1 beta, sICAM-1, and TNF-alpha compared to controls (p < 0.001).
Why the study?
Are serum concentrations of inflammatory cytokines elevated in patients with stable angina and acute myocardial infarction compared to controls?
Observational (n=69)
Are serum concentrations of inflammatory cytokines elevated in patients with stable angina and acute myocardial infarction compared to controls?
p-value: p=< 0.001
Inflammatory cytokines are elevated in both stable angina and acute myocardial infarction, with IL-6 being particularly elevated during acute infarction.
Cytokine differences may aid acute vs stable syndrome differentiation; case-control data leave prognostic and therapeutic roles open.
The changes in serum concentrations of cytokines such as interleukin-1 (IL-1) beta, interleukin-6 (IL-6), tumor necrosis factor (TNF) alpha and a soluble-intercellular adhesion molecule (sICAM-1) has been investigated in patients with stable angina and acute myocardial infarction. Thirty-four patients with stable angina (SA), 15 with acute myocardial infarction (AMI), and 20 subjects in the control (C) group were included in the study. The mean serum concentrations of sICAM-1, IL-1-beta, IL-6, and TNF-alpha differed significantly among the three groups. Serum concentrations of IL-1 beta, sICAM-1, and TNF-alpha were comparable in the AMI and SA groups and higher than those found in the C group (p < 0.001). The serum concentration of IL-6 was more than twice as high in the AMI group as compared to the other two groups (p < 0.001). The mean serum concentrations of IL-1 beta, TNF-alpha, and IL-6 were comparable in the AMI and SA groups and higher than in the C group.
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Balbay et al. (2001) conducted an observational in Chronic Stable Angina and Acute Myocardial Infarction (n=69). Acute myocardial infarction and stable angina vs. Control group was evaluated on Serum concentrations of sICAM-1, IL-1-beta, IL-6, and TNF-alpha (p=< 0.001). Patients with acute myocardial infarction and stable angina had significantly higher serum concentrations of IL-1 beta, sICAM-1, and TNF-alpha compared to controls (p < 0.001).
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