Key result
Stable angina pectoris was associated with significantly elevated serum levels of IL-1β (116.80 vs 88.79 pg/ml in males, p<0.01) and IL-6 (5.57 vs 4.46 ng/L in males, p<0.05) compared to healthy controls.
Why the study?
Inflammatory mediators released by injured endothelium contribute to atherosclerosis, prompting investigation into whether IL-1β, IL-5, IL-6, and IL-8 serve as diagnostic markers in stable angina pectoris.
Are serum levels of IL-1β, IL-5, IL-6, and IL-8 elevated in patients with stable angina pectoris compared to healthy individuals?
Case-Control (n=50)
No
Are serum levels of IL-1β, IL-5, IL-6, and IL-8 elevated in patients with stable angina pectoris compared to healthy individuals?
Absolute Event Rate: 116.8% vs 88.79%
p-value: p=<0.01
Proinflammatory mediators IL-1β and IL-6 are significantly elevated in patients with stable angina pectoris and may serve as helpful diagnostic markers alongside standard cardiac biomarkers.
May support IL-1β and IL-6 as diagnostic adjuncts in stable angina; leaves open prospective validation before clinical adoption.
The inflammatory mediators released by injured endothelium enhance the interaction of circulating leukocytes with endothelial cells and contribute to development and progression of atherosclerosis. In this study we designed to determine some interleukins (IL-1β, IL-5, IL-6 and IL-8) as diagnostic markers instable angina pectoris. Methods: The study was carried out on 30 patients who were diagnosed with stable angina pectoris (18 males and 12 females).They visited Nasiriya Heart Center throughout the period from the beginning of November 2021 to the end of April 2022, and 20 age matched healthy person (13 males and 7 females). IL-1β, IL-5, IL-6, IL-8 were assayed by an enzyme-linked immunosorbent assay (ELISA). Troponin I (cTnl) was determined by using monoclonal cTnI-specific antibody. D- dimer by electro-chemiluminescence method. CK-MB by monoclonal CK-MB-specific antibody. Myoglobin by monoclonal MYO-specific antibody. Results: Male and female patients with stable angina showed significantly elevated serum levels of troponin (P<0.001), D-dimer (P<0.001) and (P<0.01) respectively, CK-MB (P<0.01), myoglobin (P<0.01), IL-1β (P<0.01 and <0.05 respectively) and IL-6 (P<0.05), with non-significant changes in the levels of IL-5 and IL-8 in comparison with healthy male and female individuals respectively. Conclusion: In addition to troponin, D-dimer, CK-MB and myoglobin; the proinflammatory mediators such as IL-1β, and IL-6 are helpful diagnostic markers instable angina pectoris.
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Khalid et al. (2023) conducted a case-control in Stable angina pectoris (n=50). Stable angina pectoris vs. Healthy controls was evaluated on Serum IL-1β levels in males (pg/ml) (p=<0.01). Stable angina pectoris was associated with significantly elevated serum levels of IL-1β (116.80 vs 88.79 pg/ml in males, p<0.01) and IL-6 (5.57 vs 4.46 ng/L in males, p<0.05) compared to healthy controls.
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