Why the study?
Proinflammatory cytokines and chemokines may drive endothelial dysfunction and atherosclerotic plaque formation, prompting evaluation of select cytokines and cardiac markers for diagnosis and follow-up in stable angina pectoris.
Does percutaneous coronary intervention alter serum levels of inflammatory cytokines and cardiac markers in patients with stable angina pectoris compared to healthy controls?
Case-Control (n=70)
No
Does percutaneous coronary intervention alter serum levels of inflammatory cytokines and cardiac markers in patients with stable angina pectoris compared to healthy controls?
Absolute Event Rate: 115.32% vs 88.79%
p-value: p=<0.001
Inflammatory cytokines (IL-1β, IL-5, IL-6, IL-8) and cardiac markers are elevated in stable angina patients and normalize one week after PCI, suggesting their utility as diagnostic and follow-up markers.
May support cytokines as diagnostic/follow-up markers in stable angina; hypothesis-generating, should not yet change practice.
Background and aims: Angina pectoris is the discomfort felt when the heart muscle does not receive enough oxygen. The definition of stable angina is the presence of symptoms only with exertion. Chest pain, or its angina equivillant, is a defining feature, and it is relieved by rest or nitroglycerin when exercise is ceased. Often, this is one of the first symptoms or warning indications of underlying coronary disease. The proinflammatory state is believed to aggravate endothelial dysfunction by activating endothelial cells, releases cytokines and chemokines, which may be crucial in the atherosclerotic plaque formation which is the primary cause of angina pectoris. We studied the value of some cytokines and cardiac markers as a diagnostic and follow up markers in patients with stable angina. Methodology: The study was carried out on 50 patients diagnosed with stable angina pectoris, who visited Nasiriya Heart Center throughout the period from December 2021 to April 2022, and 20 age matched healthy person. IL-1β, IL-5, IL-6, IL-8 were assayed at baseline (hospital admission), 1 day and 1 week post-PCI by an enzyme-linked immunosorbent assay (ELISA).
No takes yet. Share an insight, caveat, or question.
Khalid et al. (2022) conducted a case-control in Stable angina pectoris (n=70). Stable angina pectoris vs. Healthy controls was evaluated on Serum IL-1β levels in males pre-PCI (pg/ml) (p=<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: