Key result
Stable angina pectoris was associated with significantly elevated baseline serum levels of IL-1β, IL-6, and IL-8 compared to healthy controls, which returned to normal limits one week after percutaneous coronary intervention.
Why the study?
Proinflammatory cytokines may play a crucial role in atherosclerotic plaque formation causing angina, motivating evaluation of cytokines and cardiac markers for diagnosis and follow-up in stable angina pectoris.
Does percutaneous coronary intervention (PCI) alter serum levels of inflammatory cytokines and cardiac markers in patients with stable angina pectoris compared to healthy controls?
Observational (n=70)
No
Does percutaneous coronary intervention (PCI) alter serum levels of inflammatory cytokines and cardiac markers in patients with stable angina pectoris compared to healthy controls?
Absolute Event Rate: 115.32% vs 88.79%
p-value: p=<0.001
Proinflammatory cytokines and cardiac markers are elevated in stable angina patients and normalize one week post-PCI, suggesting their utility in diagnosis and follow-up.
Cytokine normalization post-PCI may support adjunctive monitoring in stable angina; hypothesis-generating, needs prospective validation before practice change.
Background and aims: Angina pectoris is the discomfort felt when the heart muscle does not receive enough oxygen. The definition of stable angina is the presence of symptoms only with exertion. Chest pain, or its angina equivillant, is a defining feature, and it is relieved by rest or nitroglycerin when exercise is ceased. Often, this is one of the first symptoms or warning indications of underlying coronary disease. The proinflammatory state is believed to aggravate endothelial dysfunction by activating endothelial cells, releases cytokines and chemokines, which may be crucial in the atherosclerotic plaque formation which is the primary cause of angina pectoris. We studied the value of some cytokines and cardiac markers as a diagnostic and follow up markers in patients with stable angina. Methodology: The study was carried out on 50 patients diagnosed with stable angina pectoris, who visited Nasiriya Heart Center throughout the period from December 2021 to April 2022, and 20 age matched healthy person. IL-1β, IL-5, IL-6, IL-8 were assayed at baseline (hospital admission), 1 day and 1 week post-PCI by an enzyme-linked immunosorbent assay (ELISA). In addition, Troponin I (cTnl) was determined by using monoclonal cTnI-specific antibody.
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Khalid et al. (2022) conducted an observational in Stable angina pectoris (n=70). Stable angina pectoris vs. Age-matched healthy controls was evaluated on Serum IL-1β levels in male patients pre-PCI (pg/ml) (p=<0.001). Stable angina pectoris was associated with significantly elevated baseline serum levels of IL-1β, IL-6, and IL-8 compared to healthy controls, which returned to normal limits one week after percutaneous coronary intervention.
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