What question did this study set out to answer?

To determine whether serum concentrations of the anti-inflammatory cytokine interleukin-10 differ between patients with chronic stable angina and those with unstable angina.

August 14, 2001Circulation

Serum Levels of the Antiinflammatory Cytokine Interleukin-10 Are Decreased in Patients With Unstable Angina

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Why the study?

Are serum IL-10 concentrations decreased in patients with unstable angina compared to those with chronic stable angina?

Population

95 patients with angina pectoris and angiographically documented coronary artery disease

Comparison

Unstable angina vs Chronic stable angina

Design

Cross-sectional

Authors

DSDavid A. SmithFraternal Order of Eagles SISandra D. IrvingSt George's Hospital DCDella ColeElectrophysiology

Discussion

Member takes

Implication

IL-10 may protect against plaque instability; cross-sectional data leave open causal and therapeutic implications.

Key Points

To determine whether serum concentrations of the anti-inflammatory cytokine interleukin-10 differ between patients with chronic stable angina and those with unstable angina.
Studied 95 patients with angiographically confirmed coronary artery disease, categorized into chronic stable angina (n=50) or Braunwald class IIIB unstable angina with ST-segment changes (n=45).
Collected blood on admission to measure serum concentrations of interleukin-10 and interleukin-6 using commercial immunoassays.
Serum interleukin-10 concentrations were significantly lower in patients with unstable angina than in those with chronic stable angina (14.0 vs. 28.4 pg/mL; 95% CI for difference, 9.8 to 19.0; P<0.0001), persisting after multivariable adjustment.
Serum interleukin-6 concentrations were significantly elevated in the unstable angina cohort compared with the stable angina cohort (20.9 vs. 11.4 pg/mL; 95% CI for difference, 1.0 to 12.6; P=0.04).

Structured PICO

Are serum IL-10 concentrations decreased in patients with unstable angina compared to those with chronic stable angina?

Population

95 patients with angina pectoris and angiographically documented coronary artery disease (50 with chronic stable angina with stable symptoms over 3 months, and 45 with Braunwald class IIIB unstable angina with ST-segment changes)

Intervention

Unstable angina (Braunwald class IIIB with ST-segment changes)

Comparator

Chronic stable angina

Outcome

Serum IL-10 concentrations on admissionsurrogate

Patients with unstable angina have significantly lower serum levels of the anti-inflammatory cytokine IL-10 compared to those with stable angina, supporting a protective role for IL-10 in atherosclerosis.

Cite This Study

Smith et al. (2001) studied this question.

synapsesocial.com/papers/6a85cda1cf8e1b2ff031a9ca https://doi.org/10.1161/hc3201.094973

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Serum Levels of the Antiinflammatory Cytokine Interleukin-10 Are Decreased in Patients With Unstable Angina

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Serum Levels of the Antiinflammatory Cytokine Interleukin-10 Are Decreased in Patients With Unstable Angina

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider