Key result
Acute coronary syndromes were associated with significantly higher serum TNFalpha (MI 22.0 vs controls 8.3 pg/ml; p<0.001) and IL-2 levels compared to stable angina and healthy volunteers.
Population
189 patients with coronary artery disease and 20 healthy volunteers.
Design
Cohort
Follow-up
up to 30 days
Authors
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Supports inflammatory role in ACS; hypothesis-generating for cytokine-targeted therapies, should not yet change practice.
Observational (n=209)
p-value: p=<0.001
Acute coronary syndromes are associated with a prolonged increase in both pro- and anti-inflammatory cytokines compared to stable CAD and healthy subjects.
Mizia‐Stec et al. (2003) conducted an observational in Coronary artery disease (n=209). Acute coronary syndromes (myocardial infarction and unstable angina) vs. Stable angina and healthy volunteers was evaluated on Serum concentrations of TNFalpha, IL-10, and IL-2 (p=<0.001). Acute coronary syndromes were associated with significantly higher serum TNFalpha (MI 22.0 vs controls 8.3 pg/ml; p<0.001) and IL-2 levels compared to stable angina and healthy volunteers.
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