Why the study?
Does aspirin reduce proinflammatory cytokines and CRP in patients with chronic stable angina and ischemia?
Population
60 patients with chronic stable angina and 24 matched controls. A subset of 40 patients with ischemia on…
Comparison
Aspirin for 3 weeks vs Placebo for 3 weeks
Design
RCT, randomized crossover, double blind
Follow-up
6 weeks (3 weeks per treatment phase)
Authors
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Aspirin exerts anti-inflammatory effects in chronic stable angina; confirms mechanistic contribution to its atherosclerotic benefits.
Does aspirin reduce proinflammatory cytokines and CRP in patients with chronic stable angina and ischemia?
Aspirin significantly reduces proinflammatory cytokines and CRP in patients with chronic stable angina, which may partially explain its therapeutic benefits in atherosclerosis.
Ikonomidis et al. (1999) studied this question.
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