Key result
Clopidogrel 75 mg/day showed no significant difference compared to aspirin 160 mg/day in reducing circulating inflammatory markers after one year in patients with stable coronary heart disease.
Why the study?
Does clopidogrel 75 mg/day improve circulating inflammatory markers compared to aspirin 160 mg/day in patients with stable angiographically verified CHD?
Population
206 patients with stable angiographically verified coronary heart disease who were on treatment with aspirin…
Comparison
Clopidogrel 75 mg/day for one year vs Aspirin 160 mg/day for one year
Design
RCT, Randomized to either aspirin 160 mg/day or clopidogrel 75 mg/day
Follow-up
1 year
Authors
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No difference between clopidogrel and aspirin on inflammatory markers in stable CHD; leaves open whether either modulates inflammation meaningfully.
RCT (n=206)
Does clopidogrel 75 mg/day improve circulating inflammatory markers compared to aspirin 160 mg/day in patients with stable angiographically verified CHD?
Clopidogrel and aspirin demonstrate similar anti-inflammatory effects over one year in patients with stable coronary heart disease.
Pettersen et al. (2006) conducted an RCT in stable angiographically verified coronary heart disease (n=206). Clopidogrel vs. Aspirin 160 mg/day was evaluated on Changes in circulating inflammatory markers from baseline to one month and one year. Clopidogrel 75 mg/day showed no significant difference compared to aspirin 160 mg/day in reducing circulating inflammatory markers after one year in patients with stable coronary heart disease.
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