Key result
Clopidogrel plus aspirin for 14 days did not significantly change surface expression of cellular adhesion molecules or plasma markers of coagulation and fibrinolysis compared to aspirin alone.
Why the study?
Does clopidogrel added to aspirin improve markers of inflammation, hemostasis, and fibrinolysis in patients with chronic angina pectoris?
Population
42 patients with coronary artery disease (chronic angina pectoris)
Comparison
Clopidogrel added to aspirin for 14 days vs Placebo added to aspirin for 14 days
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
14 days
Authors
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Clopidogrel added to aspirin does not improve these surrogate markers in chronic angina; confirms no short-term pleiotropic benefit on inflammation or hemostasis.
RCT (n=42)
Double-blind
Randomized
Does clopidogrel added to aspirin improve markers of inflammation, hemostasis, and fibrinolysis in patients with chronic angina pectoris?
Adding clopidogrel to aspirin for 14 days does not significantly alter surrogate markers of inflammation, hemostasis, or fibrinolysis in patients with chronic angina pectoris.
Walter et al. (2008) conducted an RCT in Coronary artery disease / Chronic angina pectoris (n=42). Clopidogrel plus aspirin vs. Aspirin alone (plus placebo) was evaluated on Cellular adhesion molecules on leukocytes, soluble adhesion molecules, and molecular markers of coagulation and fibrinolysis. Clopidogrel plus aspirin for 14 days did not significantly change surface expression of cellular adhesion molecules or plasma markers of coagulation and fibrinolysis compared to aspirin alone.
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