Key result
Pretreatment with cyclooxygenase inhibitors (indomethacin or aspirin) potentiated the pulmonary arterial pressure response to acetylcholine, whereas theophylline antagonized it.
Cyclooxygenase inhibition enhances the pulmonary pressor response to acetylcholine, suggesting ACh stimulates pulmonary vascular muscarinic cholinoceptors to cause vasoconstriction and release predominantly vasodilatory prostanoids.
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Animal data on prostanoid modulation of pulmonary responses remain hypothesis-generating; human relevance requires prospective validation.
Catravas et al. (1986) studied Vasomotor response to acetylcholine in dog lung (n=14). Indomethacin, aspirin, or theophylline vs. Baseline (before administration) was evaluated on Pulmonary arterial pressure (Pa) and upstream-to-down-stream resistance ratio (Rus/Rds) response to acetylcholine. Pretreatment with cyclooxygenase inhibitors (indomethacin or aspirin) potentiated the pulmonary arterial pressure response to acetylcholine, whereas theophylline antagonized it.
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