Key result
Patients with homozygous familial hypercholesterolemia had significantly greater maximum supravalvular aortic wall thickness (P=0.006) and smaller outer diameter (P=0.0005) than normal controls.
Why the study?
Can MRI detect and characterize aortic root atherosclerotic plaque and supravalvular aortic stenosis in patients with homozygous familial hypercholesterolemia compared to normal controls?
Population
17 patients with homozygous familial hypercholesterolemia (HFH) and 12 normal control subjects
Comparison
Morphological assessment of the aortic root… vs Normal control subjects
Design
Cross-sectional, blinded
Authors
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MRI may characterize supravalvular aortic changes in homozygous FH; leaves open prospective validation and outcome impact.
Case-Control (n=29)
Blinded
Can MRI detect and characterize aortic root atherosclerotic plaque and supravalvular aortic stenosis in patients with homozygous familial hypercholesterolemia compared to normal controls?
p-value: p=0.006, 0.0005, and 0.06
MRI is a useful imaging modality for detecting and characterizing aortic root atherosclerotic plaque and supravalvular aortic stenosis in patients with homozygous familial hypercholesterolemia.
Summers et al. (1998) conducted a case-control in Homozygous familial hypercholesterolemia (n=29). Homozygous familial hypercholesterolemia vs. Normal control subjects was evaluated on Maximum supravalvular aortic wall thickness, outer diameter (OD), and lumen cross-sectional area (CSA) (p=0.006, 0.0005, and 0.06). Patients with homozygous familial hypercholesterolemia had significantly greater maximum supravalvular aortic wall thickness (P=0.006) and smaller outer diameter (P=0.0005) than normal controls.
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