Key result
Everolimus-eluting stent implantation in pigs significantly enhanced coronary vasoconstricting responses to serotonin at the stent edges compared with nonstented control sites (P<0.01).
Why the study?
Does everolimus-eluting stent implantation induce coronary perivascular adipose tissue inflammation and hyperconstricting responses in a porcine model?
Population
Porcine model (pigs), n=40
Comparison
Everolimus-eluting stent implantation in the… vs Nonstented coronary artery (control site)
Design
Preclinical, Randomly implanted in pigs into the left anterior descending or…
Follow-up
1 month
Authors
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Animal results are hypothesis-generating for everolimus-eluting stent edge effects; human studies needed to assess relevance.
RCT (n=40)
randomly implanted
Does everolimus-eluting stent implantation induce coronary perivascular adipose tissue inflammation and hyperconstricting responses in a porcine model?
p-value: p=<0.01
Everolimus-eluting stents induce coronary perivascular adipose tissue inflammation and hyperconstricting responses in pigs, which can be assessed using 18F-FDG PET imaging.
Ohyama et al. (2017) conducted an RCT in Coronary hyperconstricting responses after drug-eluting stent implantation (n=40). Everolimus-eluting stent (EES) vs. Nonstented coronary artery was evaluated on Coronary vasoconstricting responses to intracoronary serotonin (p=<0.01). Everolimus-eluting stent implantation in pigs significantly enhanced coronary vasoconstricting responses to serotonin at the stent edges compared with nonstented control sites (P<0.01).
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