Key result
Removal of extracellular Ca2+ and Mg2+ from rabbit aortic smooth muscle cells induces an inward monovalent cation current, causing depolarization and subsequent contraction upon Ca2+ readmission.
Removal of extracellular divalent cations induces a monovalent cation current and depolarization in rabbit aortic smooth muscle cells, contributing to calcium paradox-like contraction upon calcium readmission.
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May inform vascular calcium paradox mechanisms in animal models; leaves open human arterial relevance and clinical translation.
Zakharov et al. (1999) studied this question. Removal of extracellular divalent cations (Ca2+ and Mg2+) vs. Presence of extracellular divalent cations was evaluated on Whole-cell current and vessel contraction. Removal of extracellular Ca2+ and Mg2+ from rabbit aortic smooth muscle cells induces an inward monovalent cation current, causing depolarization and subsequent contraction upon Ca2+ readmission.
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