July 1, 1997The Journal of PhysiologyOpen Access

Extracellular divalent cations block a cation non‐selective conductance unrelated to calcium channels in rat cardiac muscle

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Population

Rat cardiac muscle (papillary muscles and ventricular myocytes)

Comparison

Removal of extracellular divalent cations vs Presence of extracellular divalent cations

Design

Preclinical

Authors

KMKanigula MubagwaUniversité Catholique de Bukavu MŠMilan ŠtenglCharles University WFWillem FlamengNamibia University of Science and Technology

Discussion

Member takes

Implication

Hypothesis-generating for a novel cardiac ion conductance; leaves open its relevance to human ventricular electrophysiology.

Structured PICO

Population

Rat cardiac muscle (papillary muscles and ventricular myocytes)

Intervention

Removal of extracellular divalent cations (Ca2+ and Mg2+)

Comparator

Presence of extracellular divalent cations (Ca2+ and Mg2+)

Outcome

Resting potential (Vrest) and background conductancesurrogate

The study identifies a novel conductance pathway in rat ventricular myocytes that is permeable to monovalent cations and blocked by extracellular divalent cations.

Cite This Study

Mubagwa et al. (1997) studied this question.

synapsesocial.com/papers/6a92951afc20bdb2eea2817e https://doi.org/10.1111/j.1469-7793.1997.235bk.x

View Full Paper

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Extracellular divalent cations block a cation non‐selective conductance unrelated to calcium channels in rat cardiac muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Extracellular divalent cations block a cation non‐selective conductance unrelated to calcium channels in rat cardiac muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider