September 1, 1988The Journal of PhysiologyOpen Access

Reversal potential of the calcium current in bull‐frog atrial myocytes.

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Population

Single myocytes enzymatically isolated from bull-frog atrium

Comparison

Variations in extracellular divalent ion… vs Normal 2.5 mM [Ca2+]0 Ringer solution

Design

Preclinical

Authors

DCD L CampbellUniversity of Calgary WGWayne R. GilesQB3 JHJoseph R. HumeElectrophysiology

Discussion

Member takes

Implication

Informs amphibian Ca2+ channel models; leaves open translation to mammalian or human cardiac electrophysiology.

Structured PICO

Population

Single myocytes enzymatically isolated from bull-frog atrium

Intervention

Variations in extracellular divalent ion concentrations (Ca2+, Sr2+ and Ba2+) during voltage clamp recordings

Comparator

Normal 2.5 mM [Ca2+]0 Ringer solution

Outcome

Apparent reversal potential (Erev) of the calcium current (ICa)surrogate

The calcium channel in bull-frog atrial cells is highly selective for calcium ions, with minimal contribution from monovalent cations like sodium to the observed calcium current.

Cite This Study

Campbell et al. (1988) studied this question.

synapsesocial.com/papers/6a70ff4c31a3df8243293b69 https://doi.org/10.1113/jphysiol.1988.sp017249

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Reversal potential of the calcium current in bull‐frog atrial myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reversal potential of the calcium current in bull‐frog atrial myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider