Population
Enzymatically isolated rat ventricular myocytes and hippocampal neurons
Design
Preclinical
Authors
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Suggests divalent cations modulate cardiac Ito; hypothesis-generating for ion channel regulation and requires in vivo validation.
Divalent cations have marked and specific effects on the kinetics and voltage dependence of the transient outward K+ current, potentially serving as a regulatory mechanism in its activation.
Agus et al. (1991) studied this question.
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