Why the study?
Does extracellular acidosis and Cd2+ modulate transient outward current in rat and human ventricular myocytes?
Population
Rat and human ventricular myocytes
Comparison
Extracellular acidosis (pH 6.0) and Cd2+ vs Baseline/normal extracellular solution
Design
Preclinical
Authors
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Species differences in Ito pH sensitivity caution against rodent-to-human extrapolation; leaves open clinical relevance of acidosis-Cd2+ interactions.
Does extracellular acidosis and Cd2+ modulate transient outward current in rat and human ventricular myocytes?
Acidosis and divalent cations competitively influence the transient outward current via a similar mechanism in both rat and human ventricular myocytes, though human cells are less sensitive to acidosis.
Štengl et al. (1998) studied this question.
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