Population
Mouse ventricular and atrial cells, and guinea pig atrial and ventricular cells
Comparison
Extracellular acidic pH vs Normal pH / baseline conditions
Design
Preclinical
Key result
Extracellular acidic pH induced an outwardly rectifying chloride current in mammalian cardiac myocytes that is distinct from volume-regulated and CFTR chloride currents.
Authors
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May modulate excitability in ischemic acidosis; leaves open its role in human arrhythmia mechanisms.
The identification of a distinct acidic pH-activated chloride current in cardiac myocytes suggests a potential mechanism for action potential duration or cell volume regulation during ischemia-related cardiac acidosis.
Yamamoto et al. (2005) studied this question. Extracellular acidic pH was evaluated on Induction of outwardly rectifying Cl- current (I(Cl,acid)). Extracellular acidic pH induced an outwardly rectifying chloride current in mammalian cardiac myocytes that is distinct from volume-regulated and CFTR chloride currents.