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March 3, 2000Circulation ResearchOpen Access

A novel inwardly rectifying chloride current (I(Cl.ir)), consistent with ClC-2 channels, was identified in mouse and guinea pig cardiac myocytes, activated by hyperpolarization and hypotonic cell swelling.

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Population

Mouse and guinea pig atrial and ventricular myocytes and tissues

Design

Preclinical

Authors

DDDayue Darrel DuanLYLingyu YeFBFiona C. Britton

Discussion

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Overview

May modulate cardiac excitability and volume; leaves open relevance to human disease.

Structured PICO

P
Population
Mouse and guinea pig atrial and ventricular myocytes and tissues
I
Intervention
Electrophysiological characterization (membrane hyperpolarization, hypotonic/hypertonic conditions, pharmacological blockers) and molecular analysis (RT-PCR, Northern blot)
O
Outcome
Functional and molecular identification of a novel chloride inward rectifier (Cl.ir)surrogate

Identifies a novel chloride inward rectifier (ClC-2) in mammalian cardiac myocytes, suggesting a role in regulating cardiac electrical activity and cell volume.

Cite This Study

Duan et al. (2000) studied this question.

synapsesocial.com/papers/6a6f3f00e5469ee92be0449chttps://doi.org/10.1161/01.res.86.4.e63
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