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June 1, 1990The Journal of General PhysiologyOpen Access

Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential.

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Population

Isolated guinea pig ventricular myocytes

Design

Preclinical

Authors

RHRobert D. HarveyCCCraig D. ClarkJHJoseph R. Hume

Discussion

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Overview

Autonomic ICl modulation may alter myocyte electrophysiology; leaves open its role in human arrhythmias or therapy.

Structured PICO

P
Population
Isolated guinea pig ventricular myocytes
I
Intervention
Exposure to isoproterenol (ISO), acetylcholine (ACh), forskolin, 8-bromoadenosine 3',5'-cyclic monophosphate, and 3-isobutyl-l-methylxanthine
O
Outcome
Properties of the autonomically regulated chloride current (ICl), resting membrane potential, and action potential durationsurrogate

The autonomically regulated chloride current (ICl) is regulated via a cAMP-dependent pathway and plays a key role in modulating action potential duration and resting membrane potential in mammalian cardiac myocytes.

Cite This Study

Harvey et al. (1990) studied this question.

synapsesocial.com/papers/6a71be84660549caf2c6401ahttps://doi.org/10.1085/jgp.95.6.1077
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acidic extracellular pH-activated outwardly rectifying chloride current in mammalian cardiac myocytes2005 · 47 citations
  2. 2Beta‐adrenergic and muscarinic regulation of the chloride current in guinea‐pig ventricular cells.1991 · 53 citations
  3. 3Rate-limiting steps in activation of cardiac Cl- current revealed by photolytic application of cAMP1994 · 15 citations
  4. 4Protein kinase-dependent Cl- currents in feline ventricular myocytes.1994 · 40 citations
  5. 5A Novel Anionic Inward Rectifier in Native Cardiac Myocytes2000 · 76 citations