Population
Isolated guinea pig ventricular myocytes
Comparison
Alteration of intracellular and extracellular… vs Various intra- and extracellular chloride…
Design
Preclinical
Authors
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Does not inform clinical arrhythmia care; leaves open anion effects on human cardiac electrophysiology.
This basic electrophysiology study demonstrates that the rectification of isoproterenol-activated chloride currents in ventricular myocytes depends on intracellular anion concentration and permeability.
Overholt et al. (1993) studied this question.
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