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July 1, 1994Circulation ResearchOpen Access

Protein kinase-dependent Cl- currents in feline ventricular myocytes.

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Population

Isolated feline ventricular myocytes

Comparison

Extracellular application of phorbol… vs Control experiments in the absence of PMA or…

Design

Preclinical

Authors

KZKai ZhangPBPeggy L. BarringtonRMRicardo Martín

Discussion

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Overview

Does not inform clinical arrhythmia management; leaves open whether dual PKA/PKC phosphorylation activates human cardiac ICl.

Structured PICO

P
Population
Isolated feline ventricular myocytes
I
Intervention
Extracellular application of phorbol 12-myristate 13-acetate (PMA), isoproterenol (ISO), or forskolin (FSK)
C
Comparator
Control experiments in the absence of PMA or other interventions
O
Outcome
Activation and kinetic properties of Cl- current (ICl) measured via whole-cell patch-clamp techniquesurrogate

This preclinical study demonstrates that cardiac chloride channels in feline ventricular myocytes can be activated by phosphorylation via either protein kinase A or protein kinase C.

Cite This Study

Zhang et al. (1994) studied this question.

synapsesocial.com/papers/6a73c492f96a1419040dd294https://doi.org/10.1161/01.res.75.1.133
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