β-Adrenergic Stimulation Induces Acetylcholine to Activate ATP-Sensitive K+Current in Cat Atrial Myocytes

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Population

Cat atrial myocytes

Comparison

Exposure to 1 mumol/L isoproterenol plus ICa,L… vs Control conditions

Design

Preclinical

Authors

Discussion

Does not alter clinical practice; leaves open whether beta-adrenergic IK,ATP potentiation occurs in human atria.

Population

Cat atrial myocytes

Intervention

Exposure to 1 mumol/L isoproterenol (ISO) plus ICa,L activation between two consecutive 30-second acetylcholine (ACh) exposures

Comparator

Control conditions (no ISO exposure between ACh exposures)

Outcome

ACh-induced increases in K+ conductance (specifically ATP-sensitive K+ current, IK,ATP)surrogate

Beta-adrenergic stimulation with isoproterenol potentiates acetylcholine-induced activation of ATP-sensitive K+ currents in cat atrial myocytes.

Wang et al. (1995) studied this question.

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