Population
Frog and rat ventricular myocytes, and frog atrial myocytes
Comparison
Muscarinic acetylcholine receptor antagonists vs Basal conditions or presence of agonists without…
Design
Preclinical
Authors
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May enhance ICa after beta-stimulation in myocytes; leaves open relevance to human cardiac electrophysiology.
Muscarinic antagonists such as atropine exhibit agonist-independent stimulatory effects on L-type calcium currents in cardiac myocytes, which requires increased adenylyl cyclase activity.
Hanf et al. (1993) studied this question.
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