Key result
In guinea pig ventricular myocytes, PKC activators activated unitary Cl- channels with a mean conductance of 9.31 pS, similar to channels activated by PKA.
Population
Guinea pig ventricular myocytes (cell-attached patches)
Design
Preclinical
Authors
Loading...
Animal data suggest PKC/PKA convergence on cardiac Cl− channels; leaves open relevance to human ventricular electrophysiology or arrhythmias.
PKC and PKA activate unitary chloride channels with similar conductance and kinetic properties in guinea pig ventricular myocytes, suggesting they may modulate the same cardiac CFTR channels.
Collier et al. (1995) studied this question. PKC activators (PDBu or PMA) was evaluated on Unitary Cl- channel conductance. In guinea pig ventricular myocytes, PKC activators activated unitary Cl- channels with a mean conductance of 9.31 pS, similar to channels activated by PKA.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: