July 1, 2002AJP Heart and Circulatory Physiology

Electrophysiological response of rat ventricular myocytes to acidosis

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Why the study?

Does acidosis alter the electrophysiological properties of rat ventricular myocytes?

Population

Rat subepicardial (Epi) and subendocardial (Endo) ventricular myocytes

Comparison

Acidosis vs Control pH (7.4)

Design

Preclinical

Authors

KKKimiaki KomukaiJikei University Kashiwa hospital FBFabien BretteCentre National de la Recherche Scientifique CPCaroline PascarelUniversity of Leeds

Discussion

Member takes

Implication

These rat myocyte effects should not yet alter clinical acidosis management; leaves open mechanistic contributions to human arrhythmias.

Structured PICO

Does acidosis alter the electrophysiological properties of rat ventricular myocytes?

Population

Rat subepicardial (Epi) and subendocardial (Endo) ventricular myocytes

Intervention

Acidosis (extracellular pH decreased from 7.4 to 6.5)

Comparator

Control pH (7.4)

Outcome

Action potential, resting potential, and ionic currents (I(Ca), I(K1), I(K), I(SS), I(Cl,ir))surrogate

Acidosis prolongs the action potential via decreased steady-state current and depolarizes the resting membrane potential via increased inwardly rectifying chloride current in rat ventricular myocytes.

Cite This Study

Komukai et al. (2002) studied this question.

synapsesocial.com/papers/6a207ec7e1fa5be4a5f41d85 https://doi.org/10.1152/ajpheart.01042.2001

View Full Paper

Ask AI

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Electrophysiological response of rat ventricular myocytes to acidosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological response of rat ventricular myocytes to acidosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider