Why the study?
Does acidosis affect the transient outward potassium current in isolated rat ventricular myocytes?
Population
Isolated rat ventricular myocytes (subepicardial and subendocardial cells)
Comparison
Exposure to an acid solution (pH 6.5) vs Baseline/normal pH conditions
Design
Preclinical
Authors
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Acidosis effects on subepicardial I(to) are hypothesis-generating; leaves open relevance to human ischemia-related arrhythmias.
Does acidosis affect the transient outward potassium current in isolated rat ventricular myocytes?
Acidosis increases the amplitude of the transient outward potassium current in subepicardial rat ventricular myocytes by causing a depolarizing shift in the voltage dependence of inactivation.
Hulme et al. (2000) studied this question.
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