August 1, 1999Cardiovascular ResearchOpen Access

Sodium influx via a non-selective pathway activated by the removal of extracellular divalent cations: possible role in the calcium paradox

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Population

Rat single ventricular myocytes

Comparison

Removal of extracellular Ca2+ and Mg2+… vs Baseline conditions and repletion of Ca2+ and/or…

Design

Preclinical

Authors

SBSuzanne BosteelsJoint Research Center

Discussion

Member takes

Implication

May inform mechanisms of Ca2+ paradox in isolated myocytes; leaves open clinical relevance to reperfusion injury.

Structured PICO

Population

Rat single ventricular myocytes

Intervention

Removal of extracellular Ca2+ and Mg2+; application of nifedipine, trivalent cations (Dy3+, Gd3+, La3+; 100 microM), or gentamicin

Comparator

Baseline conditions and repletion of Ca2+ and/or Mg2+

Outcome

Membrane currents and intracellular Na+ (Nai+) accumulationsurrogate

A non-selective cation conductance distinct from L-type Ca2+ channels mediates Na+ influx during Ca2+/Mg2+-free perfusion in rat ventricular myocytes, contributing to the calcium paradox.

Cite This Study

Suzanne Bosteels (1999) studied this question.

synapsesocial.com/papers/6a858ed0f8226fba7f109fde https://doi.org/10.1016/s0008-6363(99)00098-x

View Full Paper

Ask AI

Bookmark

Sodium influx via a non-selective pathway activated by the removal of extracellular divalent cations: possible role in the calcium paradox

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sodium influx via a non-selective pathway activated by the removal of extracellular divalent cations: possible role in the calcium paradox

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider