October 1, 2001The Journal of PhysiologyOpen Access

The effect of external divalent cations on spontaneous non‐selective cation channel currents in rabbit portal vein myocytes

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Population

Outside-out patches from rabbit portal vein smooth muscle cells

Comparison

External divalent cations at various… vs 0 Ca2+ external medium

Design

Preclinical

Authors

AAAnthony P. AlbertUniversity of East Anglia WLW. A. LargeSt George's, University of London

Discussion

Member takes

Implication

Does not inform clinical vascular management; hypothesis-generating for divalent cation modulation of NSCCs in mammalian smooth muscle.

Structured PICO

Population

Outside-out patches from rabbit portal vein smooth muscle cells

Intervention

External divalent cations (Ca2+, Sr2+, Ba2+) at various concentrations (e.g., 1.5 mM, 3 microM, 100 microM)

Comparator

0 Ca2+ external medium

Outcome

Unitary conductance and kinetic behavior (open probability, open time, burst duration) of spontaneous non-selective cation channel currentssurrogate

External divalent cations significantly modulate the unitary conductance and kinetic behavior of non-selective cation channels in rabbit portal vein smooth muscle cells.

Cite This Study

Albert et al. (2001) studied this question.

synapsesocial.com/papers/6a8d1cf2d881876296cf89c0 https://doi.org/10.1111/j.1469-7793.2001.0409c.xd

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The effect of external divalent cations on spontaneous non‐selective cation channel currents in rabbit portal vein myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effect of external divalent cations on spontaneous non‐selective cation channel currents in rabbit portal vein myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider