Key result
Agents that deplete internal Ca2+ stores and inhibit calmodulin binding activate Ca2+-permeable non-selective cation channel currents in rabbit portal vein myocytes.
Population
Single rabbit portal vein myocytes
Design
Preclinical
Authors
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May link store depletion to cation channel activation in vascular myocytes; leaves open physiological role and human relevance.
Depletion of internal Ca2+ stores activates a specific Ca2+-permeable non-selective cation channel in rabbit portal vein myocytes, which may play a crucial role in refilling these stores.
Albert et al. (2002) studied this question. Depletion of internal Ca2+ stores was evaluated on Activation of Ca2+-permeable non-selective cation channel currents. Agents that deplete internal Ca2+ stores and inhibit calmodulin binding activate Ca2+-permeable non-selective cation channel currents in rabbit portal vein myocytes.
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