Large conductance calcium‐activated non‐selective cation channel in smooth muscle cells isolated from rat portal vein.

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Population

Isolated smooth muscle cells from rat portal vein

Design

Preclinical

Authors

Discussion

May modulate Ca2+ entry in portal vein myocytes; leaves open physiological role and human relevance pending further studies.

Population

Isolated smooth muscle cells from rat portal vein

Intervention

External application of caffeine (10 mM), noradrenaline (10(-5)M), acetylcholine (10(-5)M), or intracellular ryanodine (10(-5)M)

Outcome

Membrane currents and single-channel activities (conductance, reversal potential, ion permeability)surrogate

Rat portal vein smooth muscle cells possess a large conductance Ca2+-activated non-selective cation channel that is highly permeable to Ca2+.

Loirand et al. (1991) studied this question.

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