Key result
Activation of Ca(2+)-activated Cl(-) currents in murine portal vein smooth muscle cells by membrane depolarization depends on Ca(2+) entry and intracellular Ca(2+) release.
Population
Single smooth muscle cells from murine portal veins
Design
Preclinical
Authors
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Does not inform clinical practice; extends mechanistic insight into murine vascular excitability and leaves open human translation.
Ca(2+)-activated Cl(-) currents in murine portal vein smooth muscle cells depend on intracellular calcium release and play a role in vascular excitability.
Saleh et al. (2004) studied this question. Membrane depolarization and pharmacological agents was evaluated on Characterization of Ca(2+)-activated Cl(-) currents (I(ClCa)). Activation of Ca(2+)-activated Cl(-) currents in murine portal vein smooth muscle cells by membrane depolarization depends on Ca(2+) entry and intracellular Ca(2+) release.
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